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The idea was to create a new way to inhale drugs and vaccines. The article appeared in the Journal Science at a propitious time. Concerns of eliminating needles for diabetic patients drove scientists to consider inhaling insulin. This paper showed how to do it simply and led to the creation of David's first company, AIR (see Idea 4). For more check this http://www.ncbi.nlm.nih.gov/pubmed/9188534